Restylane Refyne and Defyne

Restylane Refyne and Defyne Overview

TREATS: Facial creases, particularly those around the nose and mouth

LENGTH: 10-15 minutes

ANESTHESIA: Topical numbing cream available


SIDE EFFECTS: Possible mild swelling and bruising around the injection sites for 1-2 days

RECOVERY: Patients usually return to work and other activities immediately following the procedure


Remarkable Care, Exceptional Results

“I have been getting facial fillers by Dr. Kulbersh for 5 years, and the results always match my expectations. He truly listens to what my desired outcome will look like, and consistently delivers through his expertise.

I would recommend going to Dr. Kulbersh if you are looking for natural-looking results.”

-Anonymous, RealSelf


Carolina Facial Plastics offers the Restylane fillers Refyne and Defyne, which feature innovative HA technology to ensure natural facial movement while reducing the appearance of facial creases. Our highly trained team, including Dr. Kulbersh, board-certified physician assistant Heather Bryant, and board-certified nurse practitioner Courtney Whitley, safely and effectively use Restylane Refyne and Defyne for our patients at Carolina Facial Plastics in Charlotte.

The top aesthetic destination of the south, Carolina Facial Plastics, is led by double board-certified facial plastic surgeon Dr. Jonathan Kulbersh. With his team of cosmetic experts, a fully accredited surgery center, and a private recovery retreat all located in the heart of South Park, Carolina Facial Plastics is known for unparalleled and natural-looking results exclusively for the face.

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Although patients are more aware these days of the importance of consistent skin care, the effects of aging will inevitably develop. Sometimes this occurs earlier than expected, depending on lifestyle factors and genetics. The mouth is particularly susceptible to the effects of aging, especially among those who laugh and smile frequently.

Refyne and Defyne are specifically formulated with a revolutionary technology called XpresHAn, which makes the hyaluronic acid gel softer and more pliable. This means that Refyne and Defyne are capable of delivering movements that are more fluid and natural during animation than other dermal filler treatments.

Learn more about Refyne and Defyne here.

North Carolina Hyaluronic Acid Facial Injectables

There are slight differences between Refyne and Defyne, although they are both formulated to reduce the appearance of laugh lines. Refyne is more flexible. The softer properties are suitable for patients who want gradual improvement of moderate to severe laugh lines. The results look natural and have the added effect of reducing the appearance of marionette lines (the lines running from the corners of the mouth to the chin).

Defyne is slightly firmer. It is designed to improve deeper, more severe laugh lines, as it penetrates deep to provide support to collagen and elastin. By helping support the skin at its base, the skin looks firmer and more youthful.

The best way to know for certain which filler will work best for you is to consult with a well-trained, highly skilled, board-certified facial plastic surgeon or injector in Charlotte. At Carolina Facial Plastics, we will create a treatment plan to fit your goals and needs.

Defyne is typically the best choice for deeper lines and areas where more filling is required, while Refyne works better in superficial lines and areas needing a softer fill.

Patients who have previously been wary of dermal filler treatment because the effects did not appear natural enough might find the soft properties of Refyne to be a game-changer.

More commonly, a combination treatment using both fillers together is recommended. This can be done in the same session to address different concerns in multiple areas of the face.

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Refyne and Defyne tend to work best in areas where there is more facial movement, such as around the nose and mouth. Common treatment areas include:

Restylane Refyne and Defyne can be easily reversed. There is an enzyme, hyaluronidase, which instantaneously dissolves the filler for our Charlotte patients. After injection of hyaluronidase, the face will return to its pre-injection state.

The effects of both injectable fillers last approximately 12 months.  This can vary based on the amount of filler used, the location of the filler, and the age of the patient.  Typically, fillers will last longer in an area that moves less and in areas where more filler is injected.

Because each is formulated with hyaluronic acid using “next-generation” technology, the dermal filler injections result in very little downtime. There are few side effects, which are commonly mild and temporary, including swelling, bruising, redness, itching, and soreness.

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When considering your injectable treatment options, Dr. Kulbersh recommends choosing an expert. The team at Carolina Facial Plastics is solely focused on only treatments and rejuvenation of the face and neck. Every member of our team has at least 7 years of experience and has injected thousands of patients. Our goal is to give you natural, beautiful results with every treatment.

During a consultation, Dr. Kulbersh and his team will explain the pros and cons of each injectable and devise a plan that will best suit the goals of the patient.  To learn more about how these dermal fillers address laugh lines, please contact Carolina Facial Plastics in Charlotte by completing an online form or calling 704.842.3644.

Frequently asked questions

Restylane Refyne and Defyne injections are well tolerated by patients. The use of a blunt-tipped micro-cannula improves the patient’s experience and decreases discomfort. Dr. Kulbersh has never had a patient that could not undergo filler injections because of pain. Topical numbing cream is also available upon the patient’s request.

The injection process is quick and relatively comfortable. Treatment will take anywhere from 5-20 minutes, depending on how many syringes will be used. It takes approximately five minutes per syringe to inject. This can vary, depending on the treatment location and the patient’s goals for treatment.

The number of syringes injected can depend on the severity of the wrinkles and the patient’s goals. We will customize your treatment after a thorough examination and discussion of your specific concerns.

Since most people feel they need injections when 60% of the filler is dissolved, patients will not need the same amount each treatment. If 40% of the filler remains during a touch-up treatment, the patient will need less filler to achieve the same result.

At Carolina Facial Plastics, Restylane products are priced out per syringe. Each syringe contains 1ml of product. When multiple syringes are used, the sequential syringes cost less than the initial syringe.

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Hear what Dr. Paul Nassif of Botched says about Dr. Kulbersh
Dr. Paul Nassif Hear what Dr. Paul Nassif of Botched says about Dr. Kulbersh

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