5-Fluorouracil or 5-FU is a chemotherapy agent. It is used as a treatment for cancer as it kills rapidly growing cells. While a keloid is certainly not cancer, it does share some characteristics. During the formation of a keloid, new scar tissue and skin cells are rapidly growing. Injecting 5-FU during the healing process, after the excision of a keloid, will theoretically kill any cells that are attempting to form a keloid. 5-FU is injected at the following times after a keloid excision:
- During surgery
- 2 weeks after surgery
- 4 weeks after surgery
- 6 weeks after surgery
- 4 months after surgery
- 7 months after surgery
- 1 year after surgery
Since Dr. Kulbersh has been using this algorithm for the treatment of facial keloids, his success rates at preventing the re-formation of a keloid is overwhelmingly high.